Rejuran, Vitaran or Plinest: which to choose

Three polynucleotide brands, one mechanism. The differences are practical: area, dose and price.

When someone chooses polynucleotides for the first time, the question is usually “which product is better?” The honest answer is that neither is better in itself. The difference in outcome between three certified polynucleotide products is usually smaller than the difference between a well-chosen and a badly chosen area, dose and course. There are practical differences, though, and they are worth knowing before you book.

What these actually are

Polynucleotides (PN/PDRN) are purified DNA fragments. Injected into the skin they stimulate fibroblasts — the cells that produce collagen and elastin — and improve the skin’s ability to regenerate on its own.

This is the fundamental difference from fillers: polynucleotides do not fill and do not change the shape of your face. Skin becomes denser, better hydrated and more elastic, and fine lines soften — but no one will notice that «something has been done».

All three products discussed here work exactly like that.

The three brands in short

Rejuran — PharmaResearch, South Korea. The best-known polynucleotide brand. Range: healer for the face, i for the eye area, s for scars. €250 (i) · €300 (healer, 40 mg/2 ml) · €250 (s).

HP Vitaran — BR PHARM, South Korea. The widest range by area: face, eye area, neck, décolleté, hands/hair, Vitaran S for scars and stretch marks. Sets of 2, 3 and 4 ml cover several areas in one session. From €150 per 1 ml · €200 per 2 ml · €350–400 per 3–4 ml.

Plinest — Mastelli, Italy. The oldest brand in the category. Range: Plinest, Eye, Fast, Hair. €200 per 2 ml.

Choosing in practice

One small area — the eye area only, for example — Vitaran i at €150 works out cheaper. Rejuran i for the same area costs €250.

You need 2 ml for the face — Plinest €200, Vitaran €200, Rejuran healer €300. Three products, one task, €100 between them.

Several areas in one session — face plus eye area plus neck — those sets exist only in the Vitaran range: 3 ml and 4 ml.

Scars or stretch marks — both Korean ranges have a dedicated product: Vitaran S (€150) and Rejuran s (€250).

You have had one of them before and know how your skin responded — it makes sense to continue with the same one. Switching products mid-course tells you nothing.

Why Rejuran costs more

Because the product itself costs more. The price reflects neither the result nor any «strength» — it reflects purchase cost and brand recognition. Someone who has already read about polynucleotides has most often read about Rejuran, and some people come specifically for that name. That is an understandable reason to choose it — but it is not a medical one.

What does not differ

The course. All three — 3–4 sessions, 2–3 weeks apart.
How long results last. After a full course, 6–12 months, then a maintenance session 1–2 times a year.
How it feels and recovery. A very fine needle, numbing cream for the face. Small bumps at the injection points may stay for a few hours and usually settle within 1–2 days.
Certification. All three are certified in the EU and carry the CE mark. I do not work with uncertified products.

What is actually worth comparing

Not the brand, but the dose per session and the list of areas. Two millilitres of one product and two millilitres of another are closer to each other than the marketing suggests. What matters far more is whether the area was chosen correctly, whether the dose was sufficient, and whether the course was finished.

Three sessions out of four is not “almost a course” — it is an unfinished course, and the result will reflect that. This is the most common mistake, and it has nothing to do with which product was used.

Frequently asked questions

Which of the three is best?

None is better in itself. All three are polynucleotides with the same mechanism. The choice is about area, dose and price, not about the brand.

Why does Rejuran cost more?

The product itself costs more and the brand is better known. That on its own says nothing about the result — the chosen area, the dose and a finished course matter far more.

Which is the cheapest?

It depends on the volume. One area, 1 ml — Vitaran at €150. Two millilitres for the face — Plinest or Vitaran at €200. Multi-area sets exist only in the Vitaran range.

Can I start with one and continue with another?

Switching product mid-course makes no sense — you then cannot tell what worked. Between courses, switching is fine.

How long until I see a result?

The first changes are usually visible after the second session. The full result comes once the course is finished plus another 4–6 weeks while the skin works.

Book

A consultation helps choose the product and the dose for your skin. More: HP Vitaran polynucleotides and Plinest polynucleotides.

WhatsApp +371 26071971 · Ulbrokas iela 34, Riga · every working day 10:00–19:00, by appointment only. Consultations in English, Latvian and Russian.

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